Factor V Leiden

What is Factor V Leiden?
Factor V Leiden is a blood clotting disorder.


It is not a disease.
Factor V is a protein that is needed for blood to clot properly.
Some people do not
have the normal Factor V protein.

Instead, they have an different form called
Factor V Leiden.

This is caused by a change
(mutation) in the gene for this protein.
The different gene that makes the Factor
V Leiden protein is inherited from one or
both parents.

The Factor V Leiden protein is harder to “turn off” than the normal Factor V protein.

This makes blood clots more likely to
form, a condition called thrombophilia.

If you have Factor V Leiden, you have a
greater chance of developing blood clots.
Blood clots in the deep veins in your legs
(called deep vein thrombosis or DVT)
or in your lungs (called pulmonary embolus or PE) can be dangerous.
How does Factor V Leiden affect clotting?
When you are injured, your body stops bleeding by changing

liquid blood into a
plug (clot) that blocks the leaks in damaged blood vessels.

Your body has many different proteins that
do this work.

There needs to be a balance
of these proteins to make sure there is just enough clotting power:

not enough clotting power leads to bleeding problems

too much clotting power can lead to the formation of dangerous blood clots


Factor V is one of the proteins needed to make blood form


The clotting action of
Factor V is controlled by another protein ca
lled Activated Protein C.

To stop blood
from forming clots, Activated Protein C easily turns off Factor V.


Activated Protein C does not work as well on
the abnormal Factor V Leiden protein.
Factor V Leiden resists the effects of Activat
ed Protein C, so it takes longer to turn off
Factor V Leiden.


As a result, clotting goes on
longer than usual. This is why Factor V
Leiden is sometimes called Activated Protein C Resistance                                                            and why people with this
mutation clot more than those without it.

6 thoughts on “Factor V Leiden

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  1. You’re the first person I have ever come across that has Factor V Leiden, too. Any time I mention it, no one has ever even heard of it, let alone know what it means. I take Aspirin daily and any time I have surgery, right before and then for about 10 days post-op, I give myself Louvenox injections. The way I found out I have this is because my sister had a still born at 5 1/2 months pregnant. The placenta and umbilical cord were full of blood clots. They then tested my sister and told her that it was highly likely her siblings would have this, too, but not to run out and get tested, because of insurance purposes at the time, but if we were to have surgery to be sure and mention it to our doctor and make sure they test us. So, my next surgery is when I found out about it. It’s a good thing I know because with being chronically ill and being in bed a lot, it’s good that I know and I can take aspirin, otherwise, I’m sure by now I would have had a DVT. I’ve had several superficial clots, but those you don’t have to worry about since they can’t break off and go anywhere. Just wanted to give you a shout out on this Factor V Leiden. Hope you’re doing well. Take care. Peace out!


      1. Wow! I have Avascular Necrosis, too. No one has ever mentioned that as being one of the possible causes. I was told use of steroids. I had my left hip replaced in July 2015, and my right hip will be replaced in the very near future. Very interesting to know. Have you had hip replacements already? or knees, shoulders, or ankles?

        Liked by 1 person

      2. I was diagnosed 2014 with AVN was told due to trauma since I tore my medial meniscus when doing extreme workouts

        But then I heard about dr Glueck and did blood work. And that’s how I found out I had Factor V Leiden heterogeneous .
        I’ve had no joint replacements

        Here’s some info


        Here’s link to my group

        Liked by 1 person

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